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| Jasso-Villagomez,E.I.; Garcia-Lorenzana,M.; Almanza-Perez,J.C.; Fortis-Barrera,M.A.; Blancas-Flores,G.; Roman-Ramos,R.; Prado-Barragan,L.A.; Alarcon-Aguilar,F.J.. |
| Ulomoides dermestoides is a beetle traditionally consumed to treat diabetes. In this study, we performed a composition analysis of U. dermestoides to obtain the principal fractions, which were used to assess the effect on glycemia, liver and pancreatic architecture, and PPARγ and GLUT4 expression. Normal mice and alloxan-induced diabetic mice were administered fractions of chitin, protein or fat, and the acute hypoglycemic effect was evaluated. A subacute study involving daily administration of these fractions to diabetic mice was also performed over 30 days, after which the liver and pancreas were processed by conventional histological techniques and stained with hematoxylin and eosin to evaluate morphological changes. The most active fraction, the fat... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Diabetes; Ulomoides dermestoides; Hypoglycemic agent; Insulin-sensitizing agent; Fatty acids; PPARγ. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000600606 |
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